Seahawks vs. Cardinals on Thursday Night Football: Inactives, news, live updates as Kyler Murray, Sam Darnold open up Week 4

An NFC West showdown kicks off Week 4 of the NFL season on Thursday Night Football. The Seattle Seahawks head to Arizona to take on the Cardinals in this primetime game between division foes, both sitting at 2-1 and tied for second place along with the Los Angeles Rams out west. Arizona has failed to beat Seattle in its last seven meetings, so the Cardinals will be looking to end that losing streak in Week 4.

Seattle is coming off a huge Week 3 victory where they blew out the New Orleans Saints, 44-13. The Seahawks’ special teams really shone in this one, with rookie wide receiver Tory Horton taking a punt return 95 yards for a touchdown and Dareke Young with a 60-yard kick return to set up the offense with prime field position. Quarterback Sam Darnold had an efficient game, completing 14 of 18 passes for 218 yards and two touchdowns. Kenneth Walker III also added two scores on the ground.

The challenge for this Seahawks team is to find out if they can put up points against a Cardinals defense that has allowed just 17 per game through three weeks. Seattle has scored 75 points in the past two games — both wins.

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The Cardinals come into Week 4 after a heartbreaking one-point loss to the 49ers last week, 16-15. Arizona’s fifth-ranked scoring defense did enough to get the win, but it came up short with the offense offering little support. Kyler Murray passed for just 159 yards, completing 62.8% of his passes with one touchdown. As a team, the Cardinals rushed for 106 yards but lost veteran running back James Conner for the rest of the season with a foot injury that will require surgery, putting 2024 third-round pick Trey Benson into a starting role.

Date: Thursday, September 25

Start time: 8:15 p.m. ET

Location: State Farm Stadium | Glendale, Arizona

TV channel, live stream: Amazon Prime Video